Electrical remodelling precedes heart failure in an endothelin-1-induced model of cardiomyopathy
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چکیده
منابع مشابه
Brain Remodelling following Endothelin-1 Induced Stroke in Conscious Rats
The extent of stroke damage in patients affects the range of subsequent pathophysiological responses that influence recovery. Here we investigate the effect of lesion size on development of new blood vessels as well as inflammation and scar formation and cellular responses within the subventricular zone (SVZ) following transient focal ischemia in rats (n = 34). Endothelin-1-induced stroke resul...
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BACKGROUND Elevated plasma levels of endothelin (ET)-1 have been reported in association with heart diseases, including heart failure. Furthermore, it has been suggested that ET-1 acts as a local autocrine/paracrine factor with biological activities such as vasoconstriction, mitogenesis, and inotropic effects on the heart. This study investigated alterations of ET-1, ET receptor, and endothelin...
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چکیده ندارد.
VASODILATOR EFFECTS OF THE β -AGONIST ISOPRENALINE IN AN EXPERIMENTAL MODEL OF HEART FAILURE
Heart failure is a clinical syndrome characterized by the inability of the heart to provide nutrient supply to tissues. In 75% of cases, the underlying pathology causing heart failure in patients with cardiac death is coronary heart disease. A rabbit model of heart failure with coronary ligation was produced to mimic coronary heart disease in humans. After producing the model, two arteries ...
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We investigated neuronal uptake of noradrenaline (NA) at the level of larger vessels (thoracic aorta and vena cava left renal artery and left renal vein lateral saphenous artery and lateral saphenous vein and finally central ear artery and marginal ear vein) in a model devised to mimic heart failure. The model presented here is the rabbit coronary ligation model in which myocardial infarcti...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2010
ISSN: 1755-3245,0008-6363
DOI: 10.1093/cvr/cvq351